Rosuvastatin EP Impurity K Calcium Salt (E-isomer) CAS 2290571-51-4 (free acid)
| CAS No. | 2290571-51-4 (free acid) |
| Molecular Formula | 2*C22H25FN3O5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Rosuvastatin EP Impurity K Calcium Salt (E-isomer).
Rosuvastatin EP Impurity K Calcium Salt (E-isomer) (CAS 2290571-51-4 (free acid)) is a certified pharmaceutical impurity reference standard with the molecular formula C22H25FN3O5SCa and a molecular weight of 502.59 g/mol.
Rosuvastatin EP Impurity K Calcium Salt (E-isomer) (C22H25FN3O5SCa) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Rosuvastatin EP Impurity K Calcium Salt (E-isomer) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C22H25FN3O5S Ca |
| Molecular Weight | 502.59 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Rosuvastatin Standards
- Rosuvastatin Impurity 205 (CAS 1007871-85-3)
- Rosuvastatin EP Impurity L Calcium(Mixture of Diastereomers) (CAS 1024064-70-7)
- Rosuvastatin Impurity 267 (CAS 1031246-43-1)
- Rosuvastatin Impurity 19 (CAS 1035595-71-1)
- Rosuvastatin Impurity 27 (CAS 1044518-75-3)
- Rosuvastatin Impurity 192 (CAS 1092844-00-2)
- Rosuvastatin Impurity 123 (CAS 1112048-62-0)
- Rosuvastatin Impurity 37 (CAS 1197348-98-3)
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